1.
Nucleosides Nucleotides Nucleic Acids
; 33(2): 64-79, 2014.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24660881
RESUMO
[Formula: see text]New phosphonate homodimers of 3'-azido-3'-deoxythymidine (AZT) and a phosphonate heterodimer of ß-L-2',3'-dideoxy-3'-thiacytidine (3TC) and AZT were synthesized. The compounds demonstrated moderate anti-HIV activity. Stability of the compounds in human blood serum was studied. A correlation between anti-HIV activity and stability was defined.